Dr. Brain Omnipedia Wiki

Dr. Thaddeus Puzzle Brain the Third is title character of Dr. Brain 3 and Dr. Brain 4.


He is a doctor of Puzzleometry. He is the brother of Thaddeus Egghead Brain and uncle of Dr. Elaina Brain. Much like his brother, Dr. Thaddeus Egghead Brain, Dr. T. Puzzle Brain owns his own castle. His castle is a dark and topped with creepy gargoyle heads. It is located on the cliffs of a mountainous region at the end of a treacherous road.



  • "I am Dr. Thaddeus P. Brain the Third, the P stands for Puzzle."

Behind the scenes[]

In the games it is unclear how Dr. T.P. Brain III is related to Dr. T.E. Brain from the first two games. However in Dr. Elaina’s notepad published in InterAction magazine she refers to an idea presented by her UncleDoctor in The Journal of Turbo-Science for fixing the smog problem in L.A. this indicates she is the niece of both Egghead and Puzzle Brain and her grandfather Thaddeus Puzzle Brain II wasn’t very original when naming his three sons. Elaina’s father the third brother is not known, nor if he is also a doctor.

The reference to the "Third" may be a nod to the fact that it is the third game in the series. It could even be a reference to him being the third known Dr. Brain if one includes Dr. Cranium as the first, which could make him the son of Dr. Brain from the Cole's series.